Tropism-Modification Strategies for Targeted Gene Delivery Using Adenoviral Vectors
نویسندگان
چکیده
منابع مشابه
Tropism-Modification Strategies for Targeted Gene Delivery Using Adenoviral Vectors
Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to ablate native receptor binding (i.e. CAR/integrins/heparan sulfate proteoglycans) and "bridging" interactions. "Bridging" interactions refer to co...
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ژورنال
عنوان ژورنال: Viruses
سال: 2010
ISSN: 1999-4915
DOI: 10.3390/v2102290